Association between COVID 19 exposure and expression of malignant pathological features in oral squamous cell carcinoma: A retrospective cohort study

Yufei Hua; Pingchuan Ma; Chunjie Li; Ning Gao; Zhangfan Ding

doi:10.1016/j.oraloncology.2024.106740

Association between COVID 19 exposure and expression of malignant pathological features in oral squamous cell carcinoma: A retrospective cohort study

Oral Oncol. 2024 Apr:151:106740. doi: 10.1016/j.oraloncology.2024.106740. Epub 2024 Mar 14.

Authors

Yufei Hua¹, Pingchuan Ma², Chunjie Li³, Ning Gao⁴, Zhangfan Ding⁵

Affiliations

¹ Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: scuhuayufei@163.com.
² Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: mapingchuan1997@126.com.
³ Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: lichunjie@scu.edu.cn.
⁴ Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: gaoningdaniell@163.com.
⁵ Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: dingzf16@163.com.

PMID: 38489898
DOI: 10.1016/j.oraloncology.2024.106740

Abstract

Objectives: To analyze the relationship between the clinical and pathological characters of OSCC and COVID 19 exposure.

Materials and methods: A retrospective cohort study in patients with OSCC with or without COVID 19 was performed. A total of 200 OSCC patients treated with surgery from 2019 to 2023 were included. Clinical and pathological features were analysed between two groups. Characters with statistical difference were further analysed by performing univariate analysis and logistic regression analysis.

Results: The expression of Ki67 (n = 57, 71.3 %, P < 0.001) and CyclinD1 (n = 64, 80 %, P < 0.001) in OSCC with the exposure history of COVID 19 is higher than that in patients never exposed to COVID 19. COVID 19 exposure history is an independent influencing factor for higher expression of Ki67 (OR = 4.04, 95 % CI: 1.87-8.72, P < 0.001) and CyclinD1 (OR = 5.45, 95 % CI: 2.56-11.60, P < 0.001).

Conclusion: COVID 19 may suggest more invasive malignant biological behavior of cancer cells in OSCC.

Keywords: COVID 19; CyclinD1; Ki67; Oral squamous cell carcinoma.

Publication types

Letter

MeSH terms

COVID-19*
Carcinoma, Squamous Cell* / pathology
Head and Neck Neoplasms*
Humans
Ki-67 Antigen / metabolism
Mouth Neoplasms* / pathology
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck

Substances

Ki-67 Antigen