The adverse impact of perioperative body composition abnormalities on outcomes after split liver transplantation: a multi-center retrospective cohort study

Hao Chen; Zhihang Hu; Qingguo Xu; Chiyu He; Xinyu Yang; Wei Shen; Zuyuan Lin; Huigang Li; Li Zhuang; Jinzhen Cai; Jan Lerut; Shusen Zheng; Di Lu; Xiao Xu

doi:10.1097/JS9.0000000000001303

The adverse impact of perioperative body composition abnormalities on outcomes after split liver transplantation: a multi-center retrospective cohort study

Int J Surg. 2024 Mar 15. doi: 10.1097/JS9.0000000000001303. Online ahead of print.

Authors

Hao Chen^{1

2}, Zhihang Hu^{1

2}, Qingguo Xu³, Chiyu He^{1

2}, Xinyu Yang^{1

2}, Wei Shen^{1

2}, Zuyuan Lin^{1

2}, Huigang Li^{1

2}, Li Zhuang⁴, Jinzhen Cai³, Jan Lerut⁵, Shusen Zheng^{1

2

4

6

7}, Di Lu^{1

2

7}, Xiao Xu^{1

2

7}

Affiliations

¹ Zhejiang University School of Medicine, Hangzhou, China.
² Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Hangzhou, China.
³ Organ Transplantation Center, Affiliated Hospital of Qingdao University, Qingdao, China.
⁴ Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou, China.
⁵ Starzl Unit of Abdominal Transplantation, University Hospitals Saint Luc, Université catholique Louvain, Brussels, Belgium.
⁶ Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁷ National Center for Healthcare Quality Management in Liver Transplant, Hangzhou, China.

PMID: 38489552
DOI: 10.1097/JS9.0000000000001303

Abstract

Background: Split liver transplantation increases graft availability, but its safe and effective utilization is insufficiently documented. This study aimed to investigate the association between perioperative body composition abnormalities and outcomes in adult split liver transplantation.

Materials and methods: 240 recipients who underwent split liver transplantation in three centers were enrolled in this retrospective cohort study. Body composition abnormalities including sarcopenia, myosteatosis, visceral obesity, and sarcopenic obesity were evaluated at baseline and one month after surgery using computed tomography. Their impact on outcomes including early allograft dysfunction, early complications, intensive care unit stay, graft regeneration rate and survival was analyzed.

Results: Recipients with sarcopenia or myosteatosis had a higher risk of early allograft dysfunction, higher early complication rate, and longer length of intensive care unit stay (all P<0.05), while there was no difference in graft regeneration rate. Recipient and graft survival were significantly worse for recipients with body composition abnormalities (all P<0.05). In multivariable Cox-regression analysis, sarcopenia (hazard ratio=1.765, P=0.015), myosteatosis (hazard ratio=2.066, P=0.002), and visceral obesity (hazard ratio=1.863, P=0.008) were independently associated with shorter overall survival. Piling up of the three factors increased the mortality risk stepwise (P<0.001). Recipients experienced skeletal muscle loss and muscle fat infiltration one month after surgery. Postoperative worsening sarcopenia (hazard ratio=2.359, P=0.009) and myosteatosis (hazard ratio=1.878, P=0.026) were also identified as independent risk factors for mortality.

Conclusion: Sarcopenia, myosteatosis and their progression negatively affect outcomes including early allograft dysfunction, early complications, intensive care unit stay and survival after SLT. Systemic evaluation and dynamic monitoring of body composition are valuable.