Identification of the novel HLA-DQA1*05:101 allele by next-generation sequencing in a family

HLA. 2024 Mar;103(3):e15443. doi: 10.1111/tan.15443.

Abstract

HLA-DQA1*05:101 differs from HLA-DQA1*05:01:01:02 by one nucleotide substitution at codon 221 (CGT>TGT) in exon 4.

Keywords: DQA1*05:101; HLA-DQA1; NGS; novel HLA allele.

MeSH terms

  • Alleles
  • HLA-DQ alpha-Chains / genetics
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • Sequence Analysis, DNA

Substances

  • HLA-DQA1 antigen
  • HLA-DQ alpha-Chains