The Effects of Curcumin Administration on Carotid Intima-Media Thickness and Pulse Wave Velocity in Diabetic Hemodialysis Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial

Mojtaba Ghasemiadl; Soheil Ghasemi; Alireza Soleimani; Mahsa M Esfahani; Javid Azadbakht; Hamid R Gilasi; Hamid R Talari

doi:10.4103/ijpvm.ijpvm_55_22

The Effects of Curcumin Administration on Carotid Intima-Media Thickness and Pulse Wave Velocity in Diabetic Hemodialysis Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial

Int J Prev Med. 2024 Jan 31:15:3. doi: 10.4103/ijpvm.ijpvm_55_22. eCollection 2024.

Authors

Mojtaba Ghasemiadl¹, Soheil Ghasemi¹, Alireza Soleimani², Mahsa M Esfahani¹, Javid Azadbakht¹, Hamid R Gilasi³, Hamid R Talari¹

Affiliations

¹ Department of Radiology, Kashan University of Medical Sciences, Kashan, Isfahan Province, I.R. Iran.
² Department of Internal, Kashan University of Medical Sciences, Kashan, Isfahan Province, I.R. Iran.
³ Department of Biostatistics and Epidemiology, Kashan University of Medical Sciences, Kashan, Iran.

Abstract

Background: Prior studies have reported that curcumin is inversely associated with reduced markers of atherosclerosis risk, including carotid intima-media thickness (CIMT). This study was designed to assess the effects of curcumin on CIMT and pulse wave velocity (PWV) in diabetic hemodialysis (HD) patients.

Methods: This randomized, double-blinded, placebo-controlled trial was conducted on 39 diabetic HD patients. People were assigned to receive curcumin or placebo (starch) for 24 weeks. Individuals in the curcumin group (n = 26) received 80 mg/day. CIMT and PWV levels were taken at baseline and after 24 weeks of intervention.

Results: After 24 weeks of intervention, curcumin intake did not affect mean levels of left (P = 0.83) and right (P = 0.47) CIMT and maximum levels of left (P = 0.84) and right (P = 0.11) CIMT, and PWV (P = 0.12) compared to the placebo. Furthermore, within-group difference demonstrated a significant reduction in mean levels of PWV (P = 0.01) in the curcumin group. We did not observe any significant change in C-reactive protein (CRP) concentrations after curcumin intake (P = 0.69).

Conclusions: Curcumin intake did not affect mean levels of left and right CIMT and maximum levels of left and right CIMT, PWV, and CRP levels compared to the placebo. Additionally, within-group difference demonstrated a significant reduction in mean levels of PWV in the curcumin group.This trial was registered at www.irct.ir as http://www.irct.ir: IRCT20200527047584N1.

Keywords: Carotid intima-media thickness; curcumin; diabetic hemodialysis.