Clinical Features and Prognostic Factors in Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis

Yasuyuki Takai; Akiko Yamagami; Mayumi Iwasa; Kenji Inoue; Masato Wakakura; Toshiyuki Takahashi; Keiko Tanaka

doi:10.1080/01658107.2023.2287518

Clinical Features and Prognostic Factors in Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis

Neuroophthalmology. 2023 Dec 4;48(2):134-141. doi: 10.1080/01658107.2023.2287518. eCollection 2024.

Authors

Yasuyuki Takai¹, Akiko Yamagami¹, Mayumi Iwasa¹, Kenji Inoue¹, Masato Wakakura¹, Toshiyuki Takahashi^{2

3}, Keiko Tanaka^{4

5}

Affiliations

¹ Department of Ophthalmology, Inouye Eye Hospital, Tokyo, Japan.
² Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
³ Department of Neurology, National Hospital Organization Yonezawa National Hospital, Yonezawa, Japan.
⁴ Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan.
⁵ Department of Multiple Sclerosis Therapeutics, Fukushima Medical University, Fukushima, Japan.

PMID: 38487356
PMCID: PMC10936654 (available on 2024-12-04)
DOI: 10.1080/01658107.2023.2287518

Abstract

In order to review the clinical features of anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis (MOGON), we investigated the clinical characteristics, visual function, optical coherence tomography findings, and magnetic resonance imaging of 31 patients (44 eyes). MOGON was more common in middle age without sex difference and was characterised by pain on eye movement and optic disc swelling. Magnetic resonance imaging lesions tended to be long with inflammation around the optic nerve sheath; longer lesions were associated with worse visual acuities at onset. Recurrence was significantly associated with retinal nerve fibre layer thinning, and thus, it is important to reduce recurrence as much as possible.

Keywords: Anti-myelin oligodendrocyte glycoprotein antibody; magnetic resonance imaging; optic neuritis; optical coherence tomography; recurrent optic neuritis.

Grants and funding

The authors reported there is no funding associated with the work featured in this article.