Abstract
Streptomide (1), a new amide analogue, streptomynone (2), a new quinolinone, and ten known compounds including three aliphatic acids (3-5), two amides (6-7), four cyclic dipeptides (8-11), and an adenosine (12) were isolated from the fermentation broth of Streptomyces sp. YIM S01983 isolated from a sediment sample collected in Bendong Village, Huadong Town, Chuxiong, China. Their structures were determined by analysis of the 1D/2D-NMR and HR-ESI-MS spectra. Compound 12 presented weak antimicrobial activities against Candida albicans and Aligenes faecalis (MIC=64 μg/mL). Compounds 7 and 12 showed weak cytotoxic activity against MHCC97H.
Keywords:
Streptomyces sp. YIM S01983; antimicrobial activity; antitumor activity; secondary metabolites.
© 2024 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Amides* / chemistry
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Amides* / isolation & purification
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Amides* / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Candida albicans* / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Enterococcus faecalis / drug effects
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Humans
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Microbial Sensitivity Tests*
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Molecular Structure
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Quinolones* / chemistry
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Quinolones* / isolation & purification
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Quinolones* / pharmacology
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Streptomyces* / chemistry
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Streptomyces* / metabolism
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Structure-Activity Relationship