New Analogues of Amides and Quinolinones Produced by Streptomyces sp. YIM S01983

Xia Li; Dou-Ying Zhu; Xi-Ru Liu; Hong-Jian Liu; Shu-Kun Tang; Le Cai; Li-Xing Zhao

doi:10.1002/cbdv.202400090

New Analogues of Amides and Quinolinones Produced by Streptomyces sp. YIM S01983

Chem Biodivers. 2024 Mar 14:e202400090. doi: 10.1002/cbdv.202400090. Online ahead of print.

Authors

Xia Li¹, Dou-Ying Zhu¹, Xi-Ru Liu¹, Hong-Jian Liu¹, Shu-Kun Tang², Le Cai¹, Li-Xing Zhao^{1

2}

Affiliations

¹ Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
² Yunnan Institute of Microbiology, University, Kunming, 650091, P. R.China.

PMID: 38486477
DOI: 10.1002/cbdv.202400090

Abstract

Streptomide (1), a new amide analogue, streptomynone (2), a new quinolinone, and ten known compounds including three aliphatic acids (3-5), two amides (6-7), four cyclic dipeptides (8-11), and an adenosine (12) were isolated from the fermentation broth of Streptomyces sp. YIM S01983 isolated from a sediment sample collected in Bendong Village, Huadong Town, Chuxiong, China. Their structures were determined by analysis of the 1D/2D-NMR and HR-ESI-MS spectra. Compound 12 presented weak antimicrobial activities against Candida albicans and Aligenes faecalis (MIC=64 μg/mL). Compounds 7 and 12 showed weak cytotoxic activity against MHCC97H.

Keywords: Streptomyces sp. YIM S01983; antimicrobial activity; antitumor activity; secondary metabolites.

Abstract

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