Expression and prognosis of ADAMTS18 in different tumors

Wenfei Guo; Yuying Zhang

doi:10.3389/fonc.2024.1347633

Expression and prognosis of ADAMTS18 in different tumors

Front Oncol. 2024 Feb 28:14:1347633. doi: 10.3389/fonc.2024.1347633. eCollection 2024.

Authors

Wenfei Guo¹, Yuying Zhang¹

Affiliation

¹ School of Biological Science and Technology, University of Jinan, Jinan, China.

Abstract

ADAMTS18 has been identified as an orphan member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of Zn-dependent secreted metalloproteinases since 2002. Despite the recent breakthroughs in tumor biology of ADAMTS18, there is no literature systematically discussing the relationship between ADAMTS18 and cancer. In this review, we will summarize the expression pattern and prognostic value of ADAMTS18 in various cancers. In addition, we will highlight the biological functions of ADAMTS18 in the tumor microenvironment, including the regulation of cell proliferation signals, death patterns, invasion, and migration, which influence cancer progression.

Keywords: ADAMTS18; invasion; migration; prognosis; tumor microenvironment.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by a grant from the Shandong Natural Science Foundation (No. ZR2020MH279).