SiNiSan exerts antidepressant effects by modulating serotonergic/GABAergic neuron activity in the dorsal raphe nucleus region through NMDA receptor in the adolescent depression mouse model

J Ethnopharmacol. 2024 Jun 28:328:118040. doi: 10.1016/j.jep.2024.118040. Epub 2024 Mar 11.
No abstract available

MeSH terms

  • Animals
  • Antidepressive Agents / pharmacology
  • Antidepressive Agents / therapeutic use
  • Depression / drug therapy
  • Dorsal Raphe Nucleus* / physiology
  • Drugs, Chinese Herbal*
  • GABAergic Neurons / physiology
  • Mice
  • Receptors, N-Methyl-D-Aspartate*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • shigyaku-san
  • Antidepressive Agents
  • Drugs, Chinese Herbal