Integrating of analytical techniques with enzyme-mimicking nanomaterials for the fabrication of microfluidic systems for biomedical analysis

Sherzod Shukhratovich Abdullaev; Raed H Althomali; Ahmad Raza Khan; Hijran Sanaan Jabbar; Munther Abosoda; Ali Ihsan; Saurabh Aggarwal; Yasser Fakri Mustafa; Ibrahim Hammoud Khlewee; Abeer Mhussan Jabbar

doi:10.1016/j.talanta.2024.125896

Integrating of analytical techniques with enzyme-mimicking nanomaterials for the fabrication of microfluidic systems for biomedical analysis

Talanta. 2024 Jun 1:273:125896. doi: 10.1016/j.talanta.2024.125896. Epub 2024 Mar 12.

Affiliations

¹ Faculty of Chemical Engineering, New Uzbekistan University, Tashkent, Uzbekistan; Scientific and Innovation Department, Tashkent State Pedagogical University Named After Nizami, Tashkent, Uzbekistan. Electronic address: sherzodbek.abdullaev.1001@gmail.com.
² Department of Chemistry, Prince Sattam Bin Abdulaziz University,College of Arts and Science, Wadi Al-Dawasir 11991, Saudi Arabia.
³ Department of Industrial and Manufacturing Engineering (Rachna College), University of Engineering and Technology, Lahore, 54700, Pakistan.
⁴ Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq. Electronic address: Hijran.jabbar@su.edu.krd.
⁵ Chemistry department, the Islamic University, Najaf, Iraq; Chemistry department, the Islamic University of Al Diwaniyah, Iraq; Chemistry department, the Islamic University of Babylon, Iraq.
⁶ Chemistry department, Imam Ja'afar Al-Sadiq University, Al-Muthanna 66002, Iraq.
⁷ Department of Mechanical Engineering, Uttaranchal Institute of Technology, Uttaranchal University, India.
⁸ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul-41001, Iraq.
⁹ Department of Prosthodontics, College of Health and Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq.
¹⁰ college of pharmacy/ National University of Science and Technology, Dhi Qar, Iraq.

PMID: 38479027
DOI: 10.1016/j.talanta.2024.125896

Abstract

Bioanalysis faces challenges in achieving fast, reliable, and point-of-care (POC) determination methods for timely diagnosis and prognosis of diseases. POC devices often display lower sensitivity compared to laboratory-based methods, limiting their ability to quantify low concentrations of target analytes. To enhance sensitivity, the synthesis of new materials and improvement of the efficiency of the analytical strategies are necessary. Enzyme-mimicking materials have revolutionized the field of the fabrication of new high-throughput sensing devices. The integration of microfluidic chips with analytical techniques offers several benefits, such as easy miniaturization, need for low biological sample volume, etc., while also enhancing the sensitivity of the probe. The use enzyme-like nanomaterials in microfluidic systems can offer portable strategies for real-time and reliable detection of biological agents. Colorimetry and electrochemical methods are commonly utilized in the fabrication of nanozyme-based microfluidic systems. The review summarizes recent developments in enzyme-mimicking materials-integrated microfluidic analytical methods in biomedical analysis and discusses the current challenges, advantages, and potential future directions.

Keywords: Advanced materials; Microfluidic; Nanozyme; Point-of-care; Sensor.

Publication types

Review

MeSH terms

Biosensing Techniques* / methods
Lab-On-A-Chip Devices
Microfluidic Analytical Techniques*
Microfluidics / methods
Miniaturization
Nanostructures*
Point-of-Care Systems