Expert Consensus on Ion Channel Drugs for Chronic Pain Treatment in China

Ke Ma; Zhixiang Cheng; Hao Jiang; Zhangya Lin; Chuansheng Liu; Xianguo Liu; Lijuan Lu; Yan Lu; Wei Tao; Suoliang Wang; Xiaoqiu Yang; Qishan Yi; Xiaomei Zhang; Ying Zhang; Yanqing Liu

doi:10.2147/JPR.S445171

Expert Consensus on Ion Channel Drugs for Chronic Pain Treatment in China

J Pain Res. 2024 Mar 8:17:953-963. doi: 10.2147/JPR.S445171. eCollection 2024.

Authors

Ke Ma^#¹, Zhixiang Cheng^#², Hao Jiang^#³, Zhangya Lin^#⁴, Chuansheng Liu^#⁵, Xianguo Liu^#⁶, Lijuan Lu^#⁷, Yan Lu^#⁸, Wei Tao^#⁹, Suoliang Wang^#¹⁰, Xiaoqiu Yang^#¹¹, Qishan Yi^#¹², Xiaomei Zhang^#¹³, Ying Zhang^#¹⁴, Yanqing Liu^#¹⁵

Affiliations

¹ Department of Algology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
² Department of Algology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
³ Department of Algology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
⁴ Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
⁵ Department of Algology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
⁶ Pain Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People's Republic of China.
⁷ Department of Pain Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, People's Republic of China.
⁸ Department of Algology, Xijing Hospital, The Fourth Military Medical University, Xian, People's Republic of China.
⁹ Department of Neurosurgery, Shenzhen University General Hospital, Shenzhen, People's Republic of China.
¹⁰ Department of Algology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China.
¹¹ Department of Algology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
¹² Department of Algology, The Yibin First People's Hospital Affiliated Chongqing Medical University, Yibin, People's Republic of China.
¹³ Department of Algology, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
¹⁴ Department of Algology. Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, People's Republic of China.
¹⁵ Department of Algology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

^# Contributed equally.

Abstract

Ion channel drugs have been increasing used for chronic pain management with progress in the development of selective calcium channel modulators. Although ion channel drugs have been proven safe and effective in clinical practice, uncertainty remains regarding its use to treat chronic pain. To standardize the clinical practice of ion channel drug for the treatment of chronic pain, the National Health Commission Capacity Building and Continuing Education Center for Pain Diagnosis and Treatment Special Ability Training Project established an expert group to form an expert consensus on the use of ion channel drugs for the treatment of chronic pain after repeated discussions on existing medical evidence combined with the well clinical experience of experts. The consensus provided information on the mechanism of action of ion channel drugs and their recommendations, caution use, contraindications, and precautions for their use in special populations to support doctors in their clinical decision-making.

Keywords: chronic pain; ion channel drugs; voltage-gated calcium channels; voltage-gated sodium channel.

Publication types

Review

Grants and funding

This work was supported by National Natural Science Foundation of China (peripheral mechanism of Mrgprd regulating opioid tolerance by a specific lncRNA in the dorsal root ganglion) (NSFC-82371224).