Lack of Biological Plausibility and Major Methodological Issues Cast Doubt on the Association between Aspartame and Autism. Comment on Fowler et al. Daily Early-Life Exposures to Diet Soda and Aspartame Are Associated with Autism in Males: A Case-Control Study. Nutrients 2023, 15, 3772

Nutrients. 2024 Feb 28;16(5):675. doi: 10.3390/nu16050675.

Sabrina Ayoub-Charette^{1

2}, Tauseef Ahmad Khan^{1

2}, Laura Chiavaroli^{1

2

3}, Bernadene A Magnuson⁴, John L Sievenpiper^{1

2

3

5

6}

¹ Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
² Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON M5C 2T2, Canada.
³ Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.
⁴ Health Science Consultants Inc., Collingwood, ON L9Y 0Z5, Canada.
⁵ Division of Endocrinology and Metabolism, Department of Medicine, St. Michael's Hospital, Toronto, ON M5C 2T2, Canada.
⁶ Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

Abstract

The case-control study by Fowler et al [...].