Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

Linda A J Hendricks; Katja C J Verbeek; Janneke H M Schuurs-Hoeijmakers; Arjen R Mensenkamp; Hilde Brems; Robin de Putter; Violetta C Anastasiadou; Marie-Charlotte Villy; Arne Jahn; Verena Steinke-Lange; Margherita Baldassarri; Arvids Irmejs; Mirjam M de Jong; Thera P Links; Edward M Leter; Daniëlle G M Bosch; Hildegunn Høberg-Vetti; Marianne Tveit Haavind; Kjersti Jørgensen; Lovise Mæhle; Ana Blatnik; Joan Brunet; Esther Darder; Emma Tham; Nicoline Hoogerbrugge; Janet R Vos

doi:10.3390/cancers16050953

Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

Cancers (Basel). 2024 Feb 27;16(5):953. doi: 10.3390/cancers16050953.

Authors

Linda A J Hendricks^{1

2}, Katja C J Verbeek^{1

2}, Janneke H M Schuurs-Hoeijmakers¹, Arjen R Mensenkamp^{1

2}, Hilde Brems³, Robin de Putter⁴, Violetta C Anastasiadou⁵, Marie-Charlotte Villy⁶, Arne Jahn^{7

8

9}, Verena Steinke-Lange^{10

11}, Margherita Baldassarri^{12

13

14}, Arvids Irmejs^{15

16}, Mirjam M de Jong¹⁷, Thera P Links¹⁸, Edward M Leter¹⁹, Daniëlle G M Bosch²⁰, Hildegunn Høberg-Vetti²¹, Marianne Tveit Haavind²¹, Kjersti Jørgensen²², Lovise Mæhle²², Ana Blatnik²³, Joan Brunet²⁴, Esther Darder²⁴, Emma Tham^{25

26}, Nicoline Hoogerbrugge^{1

2}, Janet R Vos^{1

2}

Affiliations

¹ Department of Human Genetics, Radboudumc Expert Center for PHTS, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
² Radboud Institute for Medical Innovation, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
³ Department of Human Genetics, University of Leuven, 3000 Leuven, Belgium.
⁴ Center for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium.
⁵ Karaiskakio Foundation, Nicosia Cyprus and Archbishop Makarios III Children's Hospital, Nicosia 2012, Cyprus.
⁶ Service de Génétique, Institut Curie, 75248 Paris, France.
⁷ Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technische Universitat Dresden, 01062 Dresden, Germany.
⁸ Hereditary Cancer Syndrome Center Dresden, 01307 Dresden, Germany.
⁹ German Cancer Consortium (DKTK), 69120 Dresden, Germany.
¹⁰ Medical Genetics Center, 80335 Munich, Germany.
¹¹ Arbeitsgruppe Erbliche Gastrointestinale Tumore, Medizinische Klinik und Poliklinik IV-Campus Innenstadt, Klinikum der Universität München, 81377 Munich, Germany.
¹² Medical Genetics, University of Siena, 53100 Siena, Italy.
¹³ Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
¹⁴ Genetica Medica, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.
¹⁵ Institute of Oncology, Riga Stradins University, 1007 Riga, Latvia.
¹⁶ Breast Unit, Pauls Stradins Clinical University Hospital, 1002 Riga, Latvia.
¹⁷ Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
¹⁸ Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
¹⁹ Department of Clinical Genetics, Maastricht University Medical Center, 6229 ER Maastricht, The Netherlands.
²⁰ Department of Clinical Genetics, Erasmus MC Rotterdam, 3015 GD Rotterdam, The Netherlands.
²¹ Western Norway Familial Cancer Center, Department of Medical Genetics, Haukeland University Hospital, 5021 Bergen, Norway.
²² Department of Medical Genetics, Oslo University Hospital, 0450 Oslo, Norway.
²³ Department of Clinical Cancer Genetics, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia.
²⁴ Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL-IDIBGI, 08916 Barcelona, Spain.
²⁵ Department of Clinical Genetics, Karolinska University Hospital, 14186 Stockholm, Sweden.
²⁶ Department of Molecular Medicine and Surgery, Karolinska Institute, 17177 Stockholm, Sweden.

Abstract

Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020-March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0-1 times/week physical activity than ≥2 times (OR_total-adj = 0.9 (95%CI 0.3-2.6); consumed daily about 1.2-1.8 times more often ≥1 than 0-1 glasses of alcohol (OR_total-adj = 1.2 (95%CI 0.4-4.0); OR_{non-breastcancer-index-adj} = 1.8 (95%CI 0.4-6.9); were about 1.04-1.3 times more often smokers than non-smokers (OR_total-adj = 1.04 (95%CI 0.4-2.8); OR_{non-breastcancer-index-adj} = 1.3 (95%CI 0.4-4.2)); and overweight or obesity (72%) was about 1.02-1.3 times less common (OR_total-adj = 0.98 (95%CI 0.4-2.6); OR_{non-breastcancer-index-adj} = 0.8 (95%CI 0.3-2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients' breast cancer risk is important.

Keywords: alcohol drinking; body mass index; breast neoplasm; exercise; hamartoma syndrome; multiple.

Abstract

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