In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p-Coumaric Acid Prenylated Derivatives

Tatiana M Vieira; Júlia G Barco; Lucas A L Paula; Paulo C A Felix; Jairo K Bastos; Lizandra G Magalhães; Antônio E M Crotti

doi:10.1002/cbdv.202400491

In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p-Coumaric Acid Prenylated Derivatives

Chem Biodivers. 2024 Mar 12:e202400491. doi: 10.1002/cbdv.202400491. Online ahead of print.

Authors

Tatiana M Vieira¹, Júlia G Barco¹, Lucas A L Paula², Paulo C A Felix², Jairo K Bastos³, Lizandra G Magalhães², Antônio E M Crotti¹

Affiliations

¹ Department of Chemistry, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, 14040-901, Ribeirão Preto, SP, Brazil.
² Research Center in Exact and Technological Sciences, University of Franca, 14404-600, Franca, SP, Brazil.
³ School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903, Ribeirão Preto, SP, Brazil.

PMID: 38470945
DOI: 10.1002/cbdv.202400491

Abstract

We have evaluated eight p-coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)-3,4-diprenyl-4-isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC₅₀=45.92 μM) and S. mansoni (IC₅₀=64.25 μM). Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p-coumaric acid prenylated derivatives.

Keywords: Leishmania amazonensis; O-prenylation; Schistosoma mansoni; artepillin C; plicatin B.

Abstract

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