An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived Streptomyces sp. CPCC 203702

Zhe Guo; Dewu Zhang; Yujia Wang; Jinglin Bai; Jun Hu; Shan Cen; Liyan Yu

doi:10.1039/d4ra01496k

An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived Streptomyces sp. CPCC 203702

RSC Adv. 2024 Mar 11;14(12):8260-8263. doi: 10.1039/d4ra01496k. eCollection 2024 Mar 6.

Authors

Zhe Guo¹, Dewu Zhang¹, Yujia Wang², Jinglin Bai^{1

2}, Jun Hu¹, Shan Cen², Liyan Yu^{1

2}

Affiliations

¹ China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 People's Republic of China zhangdewuever@163.com yly@cpcc.ac.cn.
² Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms Beijing 100050 People's Republic of China.

Abstract

A new linear thiopeptide, bernitrilecin (1), was isolated from Streptomyces sp. CPCC 203702. Compound 1 is the first example of a nitrile-bearing thiopeptide. Its structure and absolute configuration were elucidated by extensive analysis of spectroscopic data and Marfey's method. The biosynthesis of the nitrile unit for 1 was proposed to be through oxidations, decarboxylation, and dehydration. Compound 1 exhibited significant anti-influenza A virus activity with the IC₅₀ value of 16.7 μM.