Fractal-Based Morphometrics of Glioblastoma

Abstract

Morphometrics have been able to distinguish important features of glioblastoma from magnetic resonance imaging (MRI). Using morphometrics computed on segmentations of various imaging abnormalities, we show that the average and range of lacunarity and fractal dimension values across MRI slices can be prognostic for survival. We look at the repeatability of these metrics to multiple segmentations and how they are impacted by image resolution. We speak to the challenges to overcome before these metrics are included in clinical care, and the insight that they may provide.

Keywords: Glioblastoma; Imaging biomarkers; Mathematical oncology; Morphology.