Utility of 2-Chloro- N-arylacetamide and 1,1'-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]

Mostafa E Salem; Abbas H Abdullah; Magdi E A Zaki; Ismail A Abdelhamid; Ahmed H M Elwahy

doi:10.1021/acsomega.3c06653

Utility of 2-Chloro- N-arylacetamide and 1,1'-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]

ACS Omega. 2024 Feb 21;9(9):10146-10159. doi: 10.1021/acsomega.3c06653. eCollection 2024 Mar 5.

Authors

Mostafa E Salem^{1

2}, Abbas H Abdullah², Magdi E A Zaki¹, Ismail A Abdelhamid², Ahmed H M Elwahy²

Affiliations

¹ Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
² Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.

Abstract

A series of novel thieno[2,3-b]pyridines linked to N-aryl carboxamides or (carbonylphenoxy)-N-(aryl)acetamides, as well as bis(thieno[2,3-b]pyridines) linked to piperazine core via methanone or carbonylphenoxyethanone units, were synthesized by treating the appropriate chloroacetyl- or bis-bromoacetyl derivatives with 2-mercaptonicotinonitrile derivatives in ethanolic sodium ethoxide at reflux. The spectral data were used to determine the compositions of novel compounds.