A chemical magnet: Approaches to guide precise protein localization

Abstract

Small molecules that chemically induce proximity between two proteins have been widely used to precisely modulate protein levels, stability, and activity. Recently, several studies developed novel strategies that employ heterobifunctional molecules that co-opt shuttling proteins to control the spatial localization of a target protein, unlocking new potential within this domain. Together, these studies lay the groundwork for novel targeted protein relocalization modalities that can rewire the protein circuitry and interactome to influence biological outcomes.

Keywords: Chemical inducers of proximity; Heterobifunctional molecules; Protein control; Protein localization; Protein trafficking.