Primary angiosarcoma of the kidney: A challenging diagnosis

Arthur Peyrottes; Sylvain Bodard; Marc-Olivier Timsit; Arnaud Méjean; Frederic Panthier; François Audenet

doi:10.1016/j.fjurol.2024.102609

Primary angiosarcoma of the kidney: A challenging diagnosis

Fr J Urol. 2024 Mar 8;34(4):102609. doi: 10.1016/j.fjurol.2024.102609. Online ahead of print.

Authors

Arthur Peyrottes¹, Sylvain Bodard², Marc-Olivier Timsit³, Arnaud Méjean³, Frederic Panthier⁴, François Audenet³

Affiliations

¹ Service d'Urologie, Hôpital Européen Georges-Pompidou, AP-HP Centre, Université Paris Cité, 20, rue Leblanc, 75015 Paris, France. Electronic address: arthur.peyrottes@aphp.fr.
² Service d'Imagerie Adulte, Hôpital Necker-Enfants-Malades, AP-HP Centre, Université Paris Cité, Paris, France; Sorbonne Université, CNRS UMR 7371, Inserm U 1146, Laboratoire d'Imagerie Biomédicale (LIB), 75006 Paris, France.
³ Service d'Urologie, Hôpital Européen Georges-Pompidou, AP-HP Centre, Université Paris Cité, 20, rue Leblanc, 75015 Paris, France.
⁴ Service d'Urologie, Hôpital Tenon, AP-HP, Sorbonne Université, Paris, France.

PMID: 38460936
DOI: 10.1016/j.fjurol.2024.102609

Abstract

Angiosarcoma is a rare malignancy derived from endothelial cells, which behaves aggressively. Primary angiosarcoma of the kidney is even rarer, and its clinical and radiological presentations do not differ from clear cells renal cell carcinoma (ccRCC). Management protocols are not standardized, although nephrectomy is usually performed. Subsequent treatments (chemotherapy, radiotherapy, and lately, targeted therapies) vary considerably. Herein, we report the case of a middle-aged patient harboring primary angiosarcoma of the left kidney and discuss its presentation and management in light of current guidelines. The case is described for its rarity and masquerading nature.

Keywords: Aggressive course; Chemotherapy; Diagnosis; Nephrectomy; Primary angiosarcoma of the kidney; Radiotherapy; Renal angiosarcoma.