MCSdb, a database of proteins residing in membrane contact sites

Xianrun Pan; Liping Ren; Yu Yang; Yi Xu; Lin Ning; Yibing Zhang; Huaichao Luo; Quan Zou; Yang Zhang

doi:10.1038/s41597-024-03104-7

MCSdb, a database of proteins residing in membrane contact sites

Sci Data. 2024 Mar 8;11(1):281. doi: 10.1038/s41597-024-03104-7.

Authors

Xianrun Pan^#¹, Liping Ren^#², Yu Yang², Yi Xu³, Lin Ning^{2

3}, Yibing Zhang⁴, Huaichao Luo⁵, Quan Zou⁶, Yang Zhang⁷

Affiliations

¹ College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² School of Healthcare Technology, Chengdu Neusoft University, Chengdu, China.
³ School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
⁴ Glasgow College, University of Electronic Science and Technology of China, Chengdu, China.
⁵ Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. luo1987cc@163.com.
⁶ Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China. zouquan@nclab.net.
⁷ Innovative Institute of Chinese Medicine and Pharmacy, Academy for Interdiscipline, Chengdu University of Traditional Chinese Medicine, Chengdu, China. zhy1001@alu.uestc.edu.cn.

^# Contributed equally.

Abstract

Organelles do not act as autonomous discrete units but rather as interconnected hubs that engage in extensive communication by forming close contacts called "membrane contact sites (MCSs)". And many proteins have been identified as residing in MCS and playing important roles in maintaining and fulfilling specific functions within these microdomains. However, a comprehensive compilation of these MCS proteins is still lacking. Therefore, we developed MCSdb, a manually curated resource of MCS proteins and complexes from publications. MCSdb documents 7010 MCS protein entries and 263 complexes, involving 24 organelles and 44 MCSs across 11 species. Additionally, MCSdb orchestrates all data into different categories with multitudinous information for presenting MCS proteins. In summary, MCSdb provides a valuable resource for accelerating MCS functional interpretation and interorganelle communication deciphering.

MeSH terms

Cell Membrane* / chemistry
Databases, Protein*
Organelles* / chemistry
Proteins* / chemistry

Substances

Proteins