Pancytopenia following adjuvant therapy with interferon-gamma in a patient with disseminated nocardiosis

Thomas Derungs; Denis Poddubnyy; Thomas Schneider

doi:10.1016/j.ijid.2024.106997

Pancytopenia following adjuvant therapy with interferon-gamma in a patient with disseminated nocardiosis

Int J Infect Dis. 2024 May:142:106997. doi: 10.1016/j.ijid.2024.106997. Epub 2024 Mar 6.

Authors

Thomas Derungs¹, Denis Poddubnyy², Thomas Schneider²

Affiliations

¹ Department of Gastroenterology, Infectious Disease and Rheumatology, Charité Universitätsmedizin Berlin, Germany. Electronic address: thomas.derungs@charite.de.
² Department of Gastroenterology, Infectious Disease and Rheumatology, Charité Universitätsmedizin Berlin, Germany.

PMID: 38458424
DOI: 10.1016/j.ijid.2024.106997

Abstract

A patient with disseminated nocardiosis developed pancytopenia after treatment with recombinant interferon-gamma (IFN-γ). While no previous clinical reports link pancytopenia to IFN-γ, our observations align with basic research on myelosuppressive effects of IFN-γ. Adjunctive IFN-γ may improve standard nocardiosis therapy, but vigilant monitoring of its hematologic effects is necessary.

Keywords: Interferon gamma; Nocardiosis; Pancytopenia.

Publication types

Case Reports

MeSH terms

Humans
Interferon-gamma
Nocardia Infections* / diagnosis
Nocardia Infections* / drug therapy
Pancytopenia* / etiology
Recombinant Proteins / therapeutic use

Substances

Interferon-gamma
Recombinant Proteins