Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids

Eduardo Leyva-Díaz; Emily S Wilson; Guillermina López-Bendito

doi:10.1016/j.stem.2024.02.008

Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids

Cell Stem Cell. 2024 Mar 7;31(3):283-284. doi: 10.1016/j.stem.2024.02.008.

Authors

Eduardo Leyva-Díaz¹, Emily S Wilson¹, Guillermina López-Bendito²

Affiliations

¹ Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Juan de Alicante, Alicante, Spain.
² Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Juan de Alicante, Alicante, Spain. Electronic address: g.lbendito@umh.es.

PMID: 38458174
DOI: 10.1016/j.stem.2024.02.008

Abstract

Dissecting the role of the thalamus in neuropsychiatric disorders requires new models to analyze complex genetic interactions. In this issue of Cell Stem Cell, Shin et al. use patient-derived thalamocortical organoids to investigate 22q11.2 microdeletion impact on thalamic development, revealing significant transcriptional dysregulation linked to psychiatric disorders.

MeSH terms

Cerebral Cortex*
Humans
Mental Disorders* / genetics
Neural Pathways
Organoids
Thalamus