Promises and challenges of organoids: From humanized to human derived

Wenyan Wang; Yang-Xin Fu

doi:10.1016/j.stem.2024.02.002

Promises and challenges of organoids: From humanized to human derived

Cell Stem Cell. 2024 Mar 7;31(3):281-282. doi: 10.1016/j.stem.2024.02.002.

Authors

Wenyan Wang¹, Yang-Xin Fu²

Affiliations

¹ Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China; State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing 100084, China. Electronic address: wywang2022@tsinghua.edu.cn.
² Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China; State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing 100084, China. Electronic address: yangxinfu@tsinghua.edu.cn.

PMID: 38458173
DOI: 10.1016/j.stem.2024.02.002

Abstract

Kastenschmidt et al.¹ present a groundbreaking organoid culture model for follicular lymphoma, which is capable of maintaining stable compositions of B and T cells. This model is utilized in testing bispecific antibodies in effective killing of tumor B cells with the activation of T cells.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antibodies, Bispecific*
Humans
Organoids / pathology
T-Lymphocytes*

Substances

Antibodies, Bispecific