Deaminase deluge yields new opportunities for biotechnology and genome engineering

Reuben S Harris; Michael A Carpenter

doi:10.1016/j.molcel.2024.02.016

Deaminase deluge yields new opportunities for biotechnology and genome engineering

Mol Cell. 2024 Mar 7;84(5):816-818. doi: 10.1016/j.molcel.2024.02.016.

Authors

Reuben S Harris¹, Michael A Carpenter²

Affiliations

¹ Department of Biochemistry and Structural Biology and Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: rsh@uthscsa.edu.
² Department of Biochemistry and Structural Biology and Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA.

PMID: 38458171
DOI: 10.1016/j.molcel.2024.02.016

Abstract

In this issue of Molecular Cell, Vaisvila et al.¹ report a tour de force functional characterization of a large and highly diverse set of polynucleotide cytosine deaminase (PCD) enzymes, which is already propelling new biotechnology applications.

MeSH terms

Biotechnology*
Cytosine Deaminase*

Substances

Cytosine Deaminase