We introduce and study the first class of signals that can probe the dark matter in mesogenesis, which will be observable at current and upcoming large volume neutrino experiments. The well-motivated mesogenesis scenario for generating the observed matter-antimatter asymmetry necessarily has dark matter charged under the baryon number. Interactions of these particles with nuclei can induce nucleon decay with kinematics differing from spontaneous nucleon decay. We calculate the rate for this process and develop a simulation of the signal that includes important distortions due to nuclear effects. We estimate the sensitivity of DUNE, Super-Kamiokande, Hyper-Kamiokande, and JUNO to this striking signal.