Food-Related Quality of Life and Its Predictors in Inflammatory Bowel Disease

Raquel Oliveira; Viviana Martins; Helena Tavares de Sousa; Joana Roseira

doi:10.1007/s10620-024-08333-9

Food-Related Quality of Life and Its Predictors in Inflammatory Bowel Disease

Dig Dis Sci. 2024 Mar 8. doi: 10.1007/s10620-024-08333-9. Online ahead of print.

Authors

Raquel Oliveira^{1

2}, Viviana Martins^{3

4}, Helena Tavares de Sousa^{3

4}, Joana Roseira^{3

4}

Affiliations

¹ Gastroenterology Department, Algarve University Hospital Centre, Estrada do Poço Seco, 8500-338, Portimão, Portugal. raquel.f.oliveira@chua.min-saude.pt.
² Algarve Biomedical Centre (ABC), University of the Algarve, Faro, Portugal. raquel.f.oliveira@chua.min-saude.pt.
³ Gastroenterology Department, Algarve University Hospital Centre, Estrada do Poço Seco, 8500-338, Portimão, Portugal.
⁴ Algarve Biomedical Centre (ABC), University of the Algarve, Faro, Portugal.

PMID: 38457117
DOI: 10.1007/s10620-024-08333-9

Abstract

Background: Inflammatory bowel disease (IBD) is associated with dietary restrictions and food- and drink-driven daily life limitations. Food-related quality of life (FR-QoL) is still an under-addressed issue in IBD.

Aim: We aimed to study determinants of FR-QoL in an IBD cohort, namely objective measures of disease activity.

Methods: A cross-sectional case-control study was conducted in a Tertiary Hospital, including adult patients with IBD (cases) and blood donors or subjects referred for colorectal polypectomies (controls). Participants answered an anonymous multimodal questionnaire including sociodemographic and clinical data, the validated FR-QoL-29, and the SIBDQ tools. Patients' disease activity was previously assessed by a physician using symptom-based scores and biomarkers (Harvey-Bradshaw index, partial Mayo score, fecal calprotectin).

Results: A total of 239 patients with IBD and 126 controls were included. Patients with active disease had poorer FR-QoL than patients in remission (80.0 [56.0-99.0] vs. 103.5 [81.0-129.9], p < 0.001). Still, patients with IBD had significantly lower FR-QoL compared with controls (99.0 [76.0-126.0] vs. 126.0 [102.8-143.0], p < 0.001), irrespective of disease activity. FR-QoL correlated with health-related quality of life, measured by SIBDQ (r = 0.490, p < 0.001), and was significantly impaired by patients' depressive humor (84.0 [61.0-112.0] vs. 108.0 [88.0-130.5], p < 0.001). Globally, FR-QoL compromise was mostly related to persistent worries about food, concerns about food-related symptoms, and life disruption due to eating and drinking.

Conclusions: Patients with IBD showed significant FR-QoL impairment, irrespective of disease type and activity. Related psychosocial factors, such as the patient's affective status and fear around eating, warrant a need for a multidisciplinary approach to IBD, including tailored nutritional counseling.

Keywords: Diet; Food-related issues; Inflammatory bowel disease; Nutrition; Quality of life.