Pyroptosis: a new insight into intestinal inflammation and cancer

Limin Chao; Wenjing Zhang; Yuchao Feng; Pei Gao; Jinyou Ma

doi:10.3389/fimmu.2024.1364911

Pyroptosis: a new insight into intestinal inflammation and cancer

Front Immunol. 2024 Feb 22:15:1364911. doi: 10.3389/fimmu.2024.1364911. eCollection 2024.

Authors

Limin Chao¹, Wenjing Zhang¹, Yuchao Feng¹, Pei Gao¹, Jinyou Ma¹

Affiliation

¹ College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.

Abstract

Pyroptosis is an innate immune response triggered by the activation of inflammasomes by various influencing factors, characterized by cell destruction. It impacts the immune system and cancer immunotherapy. In recent years, the roles of pyroptosis and inflammasomes in intestinal inflammation and cancer have been continuously confirmed. This article reviews the latest progress in pyroptosis mechanisms, new discoveries of inflammasomes, mutual regulation between inflammasomes, and their applications in intestinal diseases. Additionally, potential synergistic treatment mechanisms of intestinal diseases with pyroptosis are summarized, and challenges and future directions are discussed, providing new ideas for pyroptosis therapy.

Keywords: cancer; gut microbiota; inflammasomes; intestinal inflammation; intestinal mucosal barrier; pyroptosis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Inflammasomes
Inflammation
Intestinal Diseases* / therapy
Neoplasms* / therapy
Pyroptosis

Substances

Inflammasomes

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China project (No. 32302921) and the Key Research Project of Higher Education Institutions in Henan Province (24A230005).