Metabolic remodeling in cancer and senescence and its therapeutic implications

Yeonju Kim; Yeji Jang; Mi-Sung Kim; Chanhee Kang

doi:10.1016/j.tem.2024.02.008

Metabolic remodeling in cancer and senescence and its therapeutic implications

Trends Endocrinol Metab. 2024 Mar 6:S1043-2760(24)00037-7. doi: 10.1016/j.tem.2024.02.008. Online ahead of print.

Authors

Yeonju Kim¹, Yeji Jang¹, Mi-Sung Kim¹, Chanhee Kang²

Affiliations

¹ School of Biological Sciences, Seoul National University, Seoul 08826, South Korea; Center for Systems Geroscience, Seoul National University, Seoul 08826, South Korea.
² School of Biological Sciences, Seoul National University, Seoul 08826, South Korea; Center for Systems Geroscience, Seoul National University, Seoul 08826, South Korea. Electronic address: chanhee.kang@snu.ac.kr.

PMID: 38453603
DOI: 10.1016/j.tem.2024.02.008

Abstract

Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells - a critical component of the aging process - undergo metabolic changes similar to cancer metabolism. A deeper understanding of the similarities and differences between these disparate pathological conditions will help identify which metabolic reprogramming is most relevant to the therapeutic liabilities of senescence. Here, we compare and contrast cancer and senescence metabolism and discuss how metabolic therapies can be established as a new modality of senotherapy for healthy aging.

Keywords: aging; cancer; metabolism; senescence; senotherapy.

Publication types

Review