Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer

Rawan Al-Faze; Hoda A Ahmed; Mohamed A El-Atawy; Hayat Zagloul; Eida M Alshammari; Mariusz Jaremko; Abdul-Hamid Emwas; Gehan M Nabil; Demiana H Hanna

doi:10.1016/j.bj.2024.100714

Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer

Biomed J. 2024 Mar 5:100714. doi: 10.1016/j.bj.2024.100714. Online ahead of print.

Authors

Rawan Al-Faze¹, Hoda A Ahmed², Mohamed A El-Atawy³, Hayat Zagloul⁴, Eida M Alshammari⁵, Mariusz Jaremko⁶, Abdul-Hamid Emwas⁷, Gehan M Nabil⁸, Demiana H Hanna⁹

Affiliations

¹ Department of Chemistry, Faculty of Science, Taibah University, Almadinah Almunawarah, 30002, Saudi Arabia. Electronic address: rafaze@taibahu.edu.sa.
² Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu, 46423, Saudi Arabia; Chemistry Department, Faculty of Science, Cairo University, 12613-Giza, Egypt. Electronic address: hmahmoud@taibahu.edu.sa.
³ Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu, 46423, Saudi Arabia; Chemistry Department, Faculty of Science, Alexandria University, Ibrahemia, P.O. Box 426, Alexandria, 21321, Egypt. Electronic address: maatawy@taibahu.edu.sa.
⁴ Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu, 46423, Saudi Arabia. Electronic address: hdzaghloul@taibahu.edu.sa.
⁵ Department of Chemistry, College of Sciences, University of Ha'il, Ha'il, 55473, Saudi Arabia. Electronic address: eida.alshammari@uoh.edu.sa.
⁶ Biological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia. Electronic address: Mariusz.jaremko@kaust.edu.sa.
⁷ Core Labs., King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia. Electronic address: abdelhamid.emwas@kaust.edu.sa.
⁸ Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia. Electronic address: gehan.nabil@gmail.com.
⁹ Chemistry Department, Faculty of Science, Cairo University, 12613-Giza, Egypt. Electronic address: dhelmy@sci.cu.edu.eg.

PMID: 38452973
DOI: 10.1016/j.bj.2024.100714

Abstract

Mitochondria are vital organelles found within living cells and have signalling, biosynthetic, and bioenergetic functions. Mitochondria play a crucial role in metabolic reprogramming, which is a characteristic of cancer cells and allows them to assure a steady supply of proteins, nucleotides, and lipids to enable rapid proliferation and development. Their dysregulated activities have been associated with the growth and metastasis of different kinds of human cancer, particularly ovarian carcinoma. In this review, we briefly demonstrated the modified mitochondrial function in cancer, including mutations in mtDNA, reactive oxygen species production, dynamics, apoptosis of cells, autophagy, and calcium excess to maintain cancer genesis, progression, and metastasis. Furthermore, the mitochondrial dysfunction pathway for some genomic, proteomic, and metabolomics modifications in ovarian cancer has been studied. Additionally, ovarian cancer has been linked to targeted therapies and biomarkers found through various alteration processes underlying mitochondrial dysfunction, notably targeting reactive oxygen species, metabolites, rewind metabolic pathways, and chemo-resistant ovarian carcinoma cells.

Keywords: Biomarkers; Mitochondria; Mitochondrial dysfunction pathway; Ovarian carcinoma; Targeted therapies.

Publication types

Review