Current treatment strategies targeting histone deacetylase inhibitors in acute lymphocytic leukemia: a systematic review

Yingjun Zhang; Ge Zhang; Yuefang Wang; Lei Ye; Luyun Peng; Rui Shi; Siqi Guo; Jiajing He; Hao Yang; Qingkai Dai

doi:10.3389/fonc.2024.1324859

Current treatment strategies targeting histone deacetylase inhibitors in acute lymphocytic leukemia: a systematic review

Front Oncol. 2024 Feb 21:14:1324859. doi: 10.3389/fonc.2024.1324859. eCollection 2024.

Authors

Yingjun Zhang^{1

2}, Ge Zhang^{1

2}, Yuefang Wang^{1

2}, Lei Ye^{1

2}, Luyun Peng^{1

2}, Rui Shi^{1

2}, Siqi Guo^{1

2}, Jiajing He^{1

2}, Hao Yang^{1

2}, Qingkai Dai^{1

2}

Affiliations

¹ Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
² Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China.

Abstract

Acute lymphocytic leukemia is a hematological malignancy that primarily affects children. Long-term chemotherapy is effective, but always causes different toxic side effects. With the application of a chemotherapy-free treatment strategy, we intend to demonstrate the most recent results of using one type of epigenetic drug, histone deacetylase inhibitors, in ALL and to provide preclinical evidence for further clinical trials. In this review, we found that panobinostat (LBH589) showed positive outcomes as a monotherapy, whereas vorinostat (SAHA) was a better choice for combinatorial use. Preclinical research has identified chidamide as a potential agent for investigation in more clinical trials in the future. In conclusion, histone deacetylase inhibitors play a significant role in the chemotherapy-free landscape in cancer treatment, particularly in acute lymphocytic leukemia.

Keywords: acute lymphocytic leukemia (ALL); chemotherapy; histone deacetylase inhibitors (HDACi); immunotherapy; targeted therapy.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by the Medical Science and Technology Project of Health Commission of Sichuan Province (No. 21PJ054).