Risk of Infective Endocarditis in Streptococcus mitis Bloodstream Infections Among Patients with Neutropenia from Hematologic Malignancies

Miranda Monk; Nikitha R Patel; Ramy Elshaboury; David W Kubiak; Sarah P Hammond

doi:10.1093/ofid/ofae063

Risk of Infective Endocarditis in Streptococcus mitis Bloodstream Infections Among Patients with Neutropenia from Hematologic Malignancies

Open Forum Infect Dis. 2024 Feb 20;11(3):ofae063. doi: 10.1093/ofid/ofae063. eCollection 2024 Mar.

Authors

Miranda Monk¹, Nikitha R Patel¹, Ramy Elshaboury¹, David W Kubiak², Sarah P Hammond^{3

4}

Affiliations

¹ Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts, USA.
² Department of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
³ Divisions of Infectious Diseases and Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁴ Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Abstract

Streptococcus mitis commonly causes bloodstream infections (BSIs) in neutropenic patients but infrequently results in infective endocarditis (IE) in this population. Among 210 patients with neutropenia and S. mitis BSI, 55% underwent cardiac imaging. None were diagnosed with S. mitis IE; 3 had recurrent S. mitis BSI within 12 weeks.

Keywords: Streptococcus mitis; bloodstream infection; endocarditis; hematologic malignancy; neutropenia.