Purpose: Oral health care is a leading unmet health care need of children with special health care needs (CSHCNs). The purposes of this study were to: (1) compare the responses of parents (parents, caregivers) of children with versus without special health care needs (SHCNs) concerning their child's functioning, oral health-related knowledge, attitudes, and behavior; and (2) assess which information parents received/wanted to receive from dentists. Methods: A total of 122 parents of CSHCNs and 115 parents of children without SHCNs responded to the surveys. Results: Parents of CSHCNs reported that their children had lower functioning (per a four-point scale, with zero indicating worst functioning; means without SHCNs/CSHCNs equal 1.98/2.70; P<0.001) and nonverbal interactions (2.24/2.77; P<0.001), flossed and used mouth rinse less frequently (per a fivepoint scale, with one indicating never: 2.23/2.70; P=0.002; 1.82/2.27; P=0.004) than parents of children without SHCNs. They reported more oral care-related challenges (43.4 percent versus 21.7 percent; P<0.001), were less comfortable helping with oral care (per a five-point answer scale, with five indicating very comfortable: 3.92/4.48; P<0.001) and less interested in receiving information (3.13/3.71; P<0.001) than parents of children without SHCNs. Conclusions: Parents of children with or without special health care needs do not differ in their knowledge and attitudes. However, parents of CSHCNs are less comfortable in helping with oral care and less interested in receiving information than parents of children without SHCNs. Understanding the obstacles parents of CSHCNs face when providing oral care for their children can help dentists better support their oral health-related efforts.