Safety and efficacy of transjugular intrahepatic portosystemic shunts vs endoscopic band ligation plus propranolol in patients with cirrhosis with portal vein thrombosis: a systematic review and meta-analysis

J Gastrointest Surg. 2024 Mar;28(3):316-326. doi: 10.1016/j.gassur.2023.12.031. Epub 2024 Jan 23.

Abstract

Background: This systematic review and meta-analysis aimed to assess the efficacy and safety of transjugular intrahepatic portosystemic shunts (TIPS) against the combined treatment of endoscopic band ligation (EBL) and propranolol in managing patients with cirrhosis diagnosed with portal vein thrombosis (PVT).

Methods: A literature search from inception to September 2023 was performed using MEDLINE, the Cochrane Library, Web of Science, and Scopus. Independent screening, data extraction, and quality assessment were performed. The main measured outcomes were the incidence and recurrence of variceal bleeding (VB), hepatic encephalopathy, and overall survival.

Results: A total of 5 studies were included. For variceal eradication, there was initially no significant difference between the groups; however, after sensitivity analysis, a significant effect emerged (risk ratio [RR], 1.55; P < .0001). TIPS was associated with a significant decrease in the incidence of VB (RR, 0.34; P < .0001) and a higher probability of remaining free of VB in the first 2 years after the procedure (first year: RR, 1.41; P < .0001; second year: RR, 1.58; P < .0001). TIPS significantly reduced the incidence of death due to acute GI bleeding compared with EBL + propranolol (RR, 0.37; P = .05).

Conclusion: TIPS offers a comprehensive therapeutic advantage over the combined EBL and propranolol regimen, especially for patients with cirrhosis with PVT. Its efficacy in variceal eradication, reducing rebleeding, and mitigating death risks due to acute GI bleeding is evident.

Keywords: Cirrhosis; Endoscopic band ligation; Portal vein thrombosis; Propranolol; Transjugular intrahepatic portosystemic shunts.

Publication types

  • Meta-Analysis
  • Systematic Review
  • Review

MeSH terms

  • Esophageal and Gastric Varices* / complications
  • Esophageal and Gastric Varices* / surgery
  • Gastrointestinal Hemorrhage / complications
  • Gastrointestinal Hemorrhage / surgery
  • Humans
  • Liver Cirrhosis / complications
  • Liver Diseases*
  • Portal Vein / surgery
  • Portasystemic Shunt, Transjugular Intrahepatic*
  • Propranolol / therapeutic use
  • Thrombosis*

Substances

  • Propranolol