Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies

Zhan Huang; Yiping Bai; Ying Chen; Ye Chen; Yuan Jiang; Jun Zhou

doi:10.3389/fphar.2024.1367170

Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies

Front Pharmacol. 2024 Feb 20:15:1367170. doi: 10.3389/fphar.2024.1367170. eCollection 2024.

Authors

Zhan Huang^#^{1

2

3}, Yiping Bai^#^{1

2}, Ying Chen^{1

2}, Ye Chen^{2

4}, Yuan Jiang⁵, Jun Zhou^{1

2}

Affiliations

¹ Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
² Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China.
³ Department of Anesthesiology, Dazhou Integrated TCM & Western Medicine Hospital, Dazhou Second People's Hospital, Dazhou, China.
⁴ Department of Traditional Chinese Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
⁵ Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.

^# Contributed equally.

Abstract

Intestinal ischemia-reperfusion injury (IRI) is a potentially severe clinical syndrome after major surgical procedures. In addition to causing intestinal mucosa injury, intestinal IRI further damages distant organs, causing the severity of the condition in patients. So far, effective therapy for intestinal IRI is still absent, and the survival rate of the patients is low. Previous experimental studies have shown that some anesthetics can alleviate intestinal IRI and protect organs while exerting their pharmacological effects, indicating that reasonable perioperative anesthesia management may provide potential benefits for patients to avoid intestinal IRI. These meaningful findings drive scholars to investigate the mechanism of anesthetics in treating intestinal IRI in-depth to discuss the possible new clinical uses. In the present mini-review, we will introduce the protective effects of different anesthetics in intestinal IRI to help us enrich our knowledge in this area.

Keywords: analgesics; anesthetic management; gas anesthetics; intravenous anesthetics; ischemia-reperfusion injury.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the grants from Research project of the Science and Technology Department of Sichuan province (2021YJ0217), the grants from the National Natural Science Foundation of China (No. 81873930), Sichuan Science and Technology Program (No. 2022YFS0615 and 2022YFS0632), Luzhou Science and Technology Program (No. 2023SYF099).