Disseminated Aspergillosis with Mediastinal Invasion Causing Fatal Stroke in an Immunocompetent Young Man

Robert Yarham; Rudy Goh; Eamon P Raith; Krishnaswamy Sundararajan; Timothy Kleinig

doi:10.1159/000536594

Disseminated Aspergillosis with Mediastinal Invasion Causing Fatal Stroke in an Immunocompetent Young Man

Case Rep Neurol. 2024 Feb 5;16(1):63-70. doi: 10.1159/000536594. eCollection 2024 Jan-Dec.

Authors

Robert Yarham¹, Rudy Goh^{1

2

3}, Eamon P Raith^{1

3}, Krishnaswamy Sundararajan^{1

4}, Timothy Kleinig^{1

5}

Affiliations

¹ Adelaide Medical School, Royal Adelaide Hospital, Adelaide, SA, Australia.
² Lyell McEwin Hospital, Elizabeth Vale, SA, Australia.
³ University of Adelaide, Adelaide, SA, Australia.
⁴ Discipline of Acute Care Medicine, University of Adelaide, Adelaide, SA, Australia.
⁵ Department of Medicine, University of Adelaide, SA, Australia.

Abstract

Introduction: Aspergillus flavus is a common cause of aspergillosis.

Case presentation: A previously fit and well, immunocompetent 27-year-old male living in Australia developed disseminated A. flavus complex infection with mediastinal and cardiac invasion, superior vena cava obstruction and stroke, with fatal haemorrhagic transformation.

Conclusion: Aspergillus Flavus is a rare but important cause of serious disease in the immunocompetent.

Keywords: Aspergillus flavus; Bronchiectasis; Case report; Invasive fungal infections; Stroke.

Publication types

Case Reports

Grants and funding

The authors have no funding sources to declare.