Dynamic Changes and Clinical Significance of Plasma Galectin-3 in Patients with Acute Ischemic Stroke Undergoing Endovascular Therapy

Mingzheng Yao; Dan Liang; Xiuli Zeng; Xiaomei Xie; Jiali Gao; Li'an Huang

doi:10.2147/JIR.S455401

Dynamic Changes and Clinical Significance of Plasma Galectin-3 in Patients with Acute Ischemic Stroke Undergoing Endovascular Therapy

J Inflamm Res. 2024 Mar 1:17:1377-1387. doi: 10.2147/JIR.S455401. eCollection 2024.

Authors

Mingzheng Yao¹, Dan Liang², Xiuli Zeng¹, Xiaomei Xie¹, Jiali Gao¹, Li'an Huang¹

Affiliations

¹ Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou, People's Republic of China.
² Department of Neurology, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, People's Republic of China.

Abstract

Purpose: Galectin-3 is a key regulator of microglial proliferation and activation and may have dual and time-dependent effects on ischemic stroke. This study aimed to prospectively investigate the dynamic changes in Galectin-3 levels in patients with acute ischemic stroke receiving endovascular therapy and its clinical significance.

Patients and methods: A total of 105 patients with acute ischemic stroke who underwent endovascular therapy were prospectively enrolled. Plasma Galectin-3 was quantitatively detected by an enzyme-linked immunosorbent assay before the operation and at 1 day, 3 days and 7 days after the operation. A linear mixed-effect model, Pearson correlation analysis and receiver operating characteristic (ROC) curve analysis were used to evaluate the dynamic changes in the plasma Galectin-3 concentration and its relationship with clinical outcomes.

Results: Increases in plasma Galectin-3 levels at 1 day and 3 days after surgery were associated with early neurological deterioration and death (both P <0.05). Increased Galectin-3 levels before surgery and at 1 day and 3 days after surgery were associated with poor prognosis (P <0.05). Pearson correlation analysis revealed that Galectin-3 levels before surgery (r =0.318, P =0.002), at 1 day (r =0.318, P =0.001), 3 days (r =0.429, P < 0.001) and 7 days after surgery (r =0.340, P =0.001) were positively correlated with NIHSS scores. The ROC curve results showed that Galectin-3 concentration had a certain predictive value for death at 1 day (AUC=0.707, P=0.013), 3 days (AUC=0.708, P=0.016) and 7 days after the operation (AUC=0.708, P=0.016), but this predictive value was lower than that of the NIHSS score.

Conclusion: In acute ischemic stroke patients receiving endovascular therapy, an increase in the plasma Galectin-3 levels were associated with death, poor prognosis, and early neurological deterioration. Galectin-3 levels were significantly correlated with the NIHSS score and had a certain predictive value for death.

Keywords: Galectin-3; dynamic change; endovascular therapy; inflammation; ischemic stroke; outcome.

Grants and funding

This study was supported by grants from National Nature Science Foundation of China (Grant Number 81971120), Guangdong Natural Science Foundation project - surface project (Grant Number 2022A1515012563), Basic and Applied Basic Research Project jointly funded by Guangzhou Science and Technology Plan Municipal Schools (institutes) (Grant Number 202201020062), National Natural Science Foundation Committee, Youth Science Fund project (Grant Number 82201438).