A meta-analysis of the association between insomnia with objective short sleep duration and risk of hypertension

Yanyuan Dai; Alexandros N Vgontzas; Le Chen; Dandan Zheng; Baixin Chen; Julio Fernandez-Mendoza; Maria Karataraki; Xiangdong Tang; Yun Li

doi:10.1016/j.smrv.2024.101914

A meta-analysis of the association between insomnia with objective short sleep duration and risk of hypertension

Sleep Med Rev. 2024 Feb 24:75:101914. doi: 10.1016/j.smrv.2024.101914. Online ahead of print.

Authors

Yanyuan Dai¹, Alexandros N Vgontzas², Le Chen¹, Dandan Zheng¹, Baixin Chen¹, Julio Fernandez-Mendoza², Maria Karataraki³, Xiangdong Tang⁴, Yun Li⁵

Affiliations

¹ Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou, Guangdong, People's Republic of China; Sleep Medicine Center, Shantou University Medical College, Shantou, Guangdong, People's Republic of China; Shantou University Medical College-Faculty of Medicine of University of Manitoba Joint Laboratory of Biological Psychiatry, People's Republic of China.
² Sleep Research and Treatment Center, Department of Psychiatry and Behavioral Health, Pennsylvania State University, College of Medicine, Hershey, PA, USA.
³ Department of Psychiatry and Behavioral Sciences, University of Crete, Heraklion, Crete, Greece.
⁴ Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
⁵ Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou, Guangdong, People's Republic of China; Sleep Medicine Center, Shantou University Medical College, Shantou, Guangdong, People's Republic of China; Shantou University Medical College-Faculty of Medicine of University of Manitoba Joint Laboratory of Biological Psychiatry, People's Republic of China. Electronic address: s_liyun@stu.edu.cn.

PMID: 38442466
DOI: 10.1016/j.smrv.2024.101914

Abstract

The aim of this meta-analysis was to examine the association between insomnia with objective short sleep duration (ISSD) with prevalent and incident hypertension in cross-sectional and longitudinal studies, respectively. Data were collected from 6 cross-sectional studies with 5914 participants and 2 longitudinal studies with 1963 participants. Odds ratios (ORs) for prevalent and risk ratios (RRs) for incident hypertension were calculated through meta-analyses of adjusted data from individual studies. Compared to normal sleepers with objective normal sleep duration (NNSD), ISSD was significantly associated with higher pooled OR for prevalent hypertension (pooled OR = 2.67, 95%CI = 1.45-4.90) and pooled RR for incident hypertension (pooled RR = 1.95, 95%CI = 1.19-3.20), respectively. Compared to insomnia with objective normal sleep duration, ISSD was associated with significantly higher pooled OR of prevalent hypertension (pooled OR = 1.94, 95%CI = 1.29-2.92) and pooled RR for incident hypertension (pooled RR = 2.07, 95%CI = 1.47-2.90), respectively. Furthermore, normal sleepers with objective short sleep duration were not associated with either prevalent (pooled OR = 1.21, 95%CI = 0.84-1.75) or incident (pooled RR = 0.97, 95%CI = 0.81-1.17) hypertension compared to NNSD. Our findings suggest that ISSD is a more severe phenotype of the disorder associated with a higher risk of hypertension. Objective short sleep duration might be a valid and clinically useful index of insomnia's impact on cardiovascular health.

Keywords: Hypertension; Insomnia; Insomnia with objective short sleep duration; Meta-analysis.

Publication types

Review