Macro-clusters: CD301b+ DCs prime Th2 responses

Hanna Abberger; Joanna R Groom

doi:10.1084/jem.20240088

Macro-clusters: CD301b+ DCs prime Th2 responses

J Exp Med. 2024 Apr 1;221(4):e20240088. doi: 10.1084/jem.20240088. Epub 2024 Mar 4.

Authors

Hanna Abberger^{1

2}, Joanna R Groom^{1

2}

Affiliations

¹ Walter and Eliza Hall Institute of Medical Research , Parkville, Australia.
² Department of Medical Biology, University of Melbourne, Parkville, Australia.

PMID: 38442269
PMCID: PMC10911086 (available on 2024-09-04)
DOI: 10.1084/jem.20240088

Abstract

In this issue of JEM, Lyons-Cohen et al. (https://doi.org/10.1084/jem.20231282) reveal that lymph node macro-clusters provide a spatial niche where CD301b+ cDC2s and CD4+ T cells interact. These integrin-mediated cellular hubs promote enhanced co-stimulation and cytokine signaling to drive Th2 differentiation.

MeSH terms

CD4-Positive T-Lymphocytes*
Cell Differentiation
Integrins*
Lymph Nodes

Substances

Integrins