The P granule antibody KT3 recognizes epitopes in both PGL-1 and PGL-3

MicroPubl Biol. 2024 Feb 16:2024:10.17912/micropub.biology.001137. doi: 10.17912/micropub.biology.001137. eCollection 2024.

Abstract

The KT3 antibody is a commercially available antibody that recognizes the P granule protein PGL-3 (Takeda et al., 2008). Using immunostaining and western blotting of purified peptide fragments, we show that KT3 recognizes both PGL-3 and its paralog PGL-1 , likely through a shared epitope in the intrinsically disordered region.