Electrochemical oxidative decarboxylative of α-oxocarboxylic acids towards the synthesis of quinazolines and quinazolinones

Jiwei Wu; Mengru Zhang; Jun He; Kaixuan Li; Longqiang Ye; Jie Zhou; Xiaolan Xu; Zirong Li; Huajian Xu

doi:10.1039/d4ra01318b

Electrochemical oxidative decarboxylative of α-oxocarboxylic acids towards the synthesis of quinazolines and quinazolinones

RSC Adv. 2024 Mar 4;14(11):7551-7556. doi: 10.1039/d4ra01318b. eCollection 2024 Feb 29.

Authors

Jiwei Wu¹, Mengru Zhang¹, Jun He¹, Kaixuan Li¹, Longqiang Ye¹, Jie Zhou², Xiaolan Xu³, Zirong Li¹, Huajian Xu²

Affiliations

¹ College of Chemistry and Materials Engineering, Anhui Science and Technology University Fengyang 233100 China lizir@ahstu.edu.cn yelq@ahstu.edu.cn.
² School of Food and Biological Engineering, Hefei University of Technology Hefei 230009 China hjxu@hfut.edu.cn.
³ School of Medical Science, Anhui Medical University Hefei 230009 China xlxu@ustc.edu.cn.

Abstract

A mild and environmentally electrochemical method for the synthesis of quinazolines and quinazolinones has been developed through anodic oxidation decarboxylative of α-oxocarboxylic acids. The present reaction was efficiently conducted by using simple and cheap NH₄I as the N-source and electrolyte in an undivided cell. The desired products, quinazolines and quinazolinones, were isolated in high yield under chemical oxidant free conditions.