Electrospun Cu-Co ferrite nanofibers: synthesis, structure, optical and magnetic properties, and anti-cancer activity

Fatimah Alahmari; Firdos Alam Khan; H Sozeri; M Sertkol; Mariusz Jaremko

doi:10.1039/d3ra08087k

Electrospun Cu-Co ferrite nanofibers: synthesis, structure, optical and magnetic properties, and anti-cancer activity

RSC Adv. 2024 Mar 4;14(11):7540-7550. doi: 10.1039/d3ra08087k. eCollection 2024 Feb 29.

Authors

Fatimah Alahmari¹, Firdos Alam Khan², H Sozeri³, M Sertkol⁴, Mariusz Jaremko⁵

Affiliations

¹ Department of Nanomedicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University P. O. Box 1982 31441 Dammam Saudi Arabia fsalahmari@iau.edu.sa.
² Department of Stem Cell Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University P. O. Box 1982 31441 Dammam Saudi Arabia.
³ TUBITAK-UME, National Metrology Institute P. O. Box 54 41470 Gebze Kocaeli Turkey.
⁴ Department of Basic Science, Deanship of Preparatory Year and Supporting Studies, Imam Abdulrahman Bin Faisal University P. O. Box 1982 Dammam 34212 Saudi Arabia.
⁵ Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology Thuwal 23955-6900 Saudi Arabia.

Abstract

In this study, we investigated Cu-Co ferrite nanofibers (NFs) that were synthesized for the first time employing the electrospinning technique. The structure, phase purity and crystallite size of all the prepared NFs were revealed by powder X-ray diffraction (PXRD) analysis. The NFs crystallized in the Fd3̄m (no. 227) space group and the cation distribution arrangement over distinct sites in their structure was analyzed. Scanning electron microscopy (SEM) together with energy-dispersive X-ray (EDX) spectroscopy analysis showed the microstructure of the NFs and verified their expected chemical compositions. High-resolution transmission electron microscopy (TEM) images confirmed the fibrous nature and the construction of the NFs. The band gap energies derived from the UV-vis reflectance spectra showed a blue shift with an increase in the amount of Cu in the sample from 1.42 eV to 1.86 eV. Magnetization (M) as a function of magnetic field (H) measurements performed at ambient and low temperatures showed the ferrimagnetic behavior of all the NFs. The magnetic parameters including coercivity (H_c), saturation magnetization (M_s), remanent magnetization (M_r), and squareness ratio were determined from the recorded magnetization curves. At 300 K, M_s was reduced from 78.8 to 42.4 emu g^-1, M_r reduced from 22.8 to 7.6 emu g^-1 and the Bohr magneton reduced from 3.3 to 1.8μ_B with an increase in the content of Cu in the samples. The same trend was observed at 10 K, where M_s was reduced from 93.7 to 50.9 emu g^-1, M_r reduced from 60.9 to 35.9 emu g^-1 and the Bohr magneton reduced from 3.94 to 2.16μ_B. Alternatively, H_c has the highest values for x = 0 (850 Oe at 300 K and 5220 Oe at 10 K) and x = 0.6 (800 Oe at 300 K and 5400 Oe at 10 K). The anti-cancer activity of the NFs was evaluated using the MTT cell viability assay, showing a reduction in the viability of both HCT-116 and HeLa cancer cells compared to non-cancerous HEK-293 cells after treatment with the NFs. Apoptotic activity was examined by DAPI staining, where treatment with the NFs induced chromatin condensation and nuclear disintegration in HCT-116 cells.