Objectives: To determine risks associated with uricosurics in COVID-19 patients.
Methods: A systematic review and meta-analysis was conducted by systematically searching electronic databases.
Key findings: The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94-1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65-0.94).
Conclusions: The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.
Keywords: COVID-19; mortality; uricosuric.
© The Author(s) 2024. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society.