Construction methods and biomedical applications of PVA-based hydrogels

Yi Zhong; Qi Lin; Han Yu; Lei Shao; Xiang Cui; Qian Pang; Yabin Zhu; Ruixia Hou

doi:10.3389/fchem.2024.1376799

Construction methods and biomedical applications of PVA-based hydrogels

Front Chem. 2024 Feb 15:12:1376799. doi: 10.3389/fchem.2024.1376799. eCollection 2024.

Authors

Yi Zhong¹, Qi Lin¹, Han Yu¹, Lei Shao², Xiang Cui³, Qian Pang¹, Yabin Zhu¹, Ruixia Hou¹

Affiliations

¹ Zhejiang Key Laboratory of Pathophysiology, Department of Cell Biology and Regenerative Medicine, Health Science Center, Ningbo University, Ningbo, China.
² Research Institute for Medical and Biological Engineering, Ningbo University, Ningbo, China.
³ Department of Otorhinolaryngology, Lihuili Hospital of Ningbo University, Ningbo, China.

Abstract

Polyvinyl alcohol (PVA) hydrogel is favored by researchers due to its good biocompatibility, high mechanical strength, low friction coefficient, and suitable water content. The widely distributed hydroxyl side chains on the PVA molecule allow the hydrogels to be branched with various functional groups. By improving the synthesis method and changing the hydrogel structure, PVA-based hydrogels can obtain excellent cytocompatibility, flexibility, electrical conductivity, viscoelasticity, and antimicrobial properties, representing a good candidate for articular cartilage restoration, electronic skin, wound dressing, and other fields. This review introduces various preparation methods of PVA-based hydrogels and their wide applications in the biomedical field.

Keywords: PVA; articular cartilage restoration; electronic skin; hydrogels; wound dressing.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (32000942), One health Interdisciplinary Research Project, Ningbo University (HY202209), the Natural Science Foundation of Ningbo (2023J082), the General Research Projects of Zhejiang Provincial Department of Education (Y202248671, Y202044155), the Natural Science Foundation of Zhejiang (LQ22C100001), Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems (GZKF-202024), Zhejiang Provincial Medical and Health Science and Technology Plan Project (2023KY241), National 111 Project of China (D16013).