Abstract
Synovial sarcomas (SSs) are a rare group of malignant tumors originating from pluripotential mesenchymal cells, which commonly occur as the primary tumor in the soft tissues near the articular surface, tendons, and articular synovium. Herein, we report a rare case of mediastinal SS in an 18-year-old teenager who initially presented with cough as the primary symptom. In this case, plain chest CT and contrast-enhanced CT clearly revealed the lesion presenting as a round-like and uneven density mass in the mediastinum with heterogeneous enhancement, which compressed the trachea and invaded the adjacent vessels. Based on the results of immunohistochemistry and fluorescence in situ hybridization (FISH), combined with the differential diagnosis with other types of tumors in the mediastinum on imaging, we were able to diagnose the tumor as an SS located in the mediastinum. Subsequent resection of the lesion coupled with chemotherapy and immunotherapy led to an improvement in the patient's symptoms.
Keywords:
chest imaging; mediastinum; mesenchymal cell; oncology; synovial sarcoma.
Copyright © 2024 Liu, Cui, Zhou, Zhai, Qin, Fan and Cai.
Grants and funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University (GZK1202136), “National Tutor System” Training Program for Health Youth Key Talents in Suzhou (Qngg2021006), Suzhou Health Talent (GSWS2021025), Suzhou Municipal Science and Technology Development Project (SKY2022049), “Image Medical Star” Project of Suzhou Medical Association (2022YX-M05), Pre-research Foundation of Second Affiliated Hospital of Soochow University (SDFEYBS1904), Project of Nuclear Technology Medical Application Supported by Discipline Construction of Second Affiliated Hospital of Soochow University (XKTJ-HRC20210010). and General Program of the 25th Batch of College Students’ Extracurricular Academic Research Fund of Soochow University (KY2023473B). This study received funding from “Technological Innovation” Project of CNNC Medical Industry Co. Ltd (ZHYLYB2021006). The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.