Advances in understanding of dendritic cell in the pathogenesis of acute kidney injury

Dongfang Lv; Huihui Jiang; Xianzhen Yang; Yi Li; Weipin Niu; Denglu Zhang

doi:10.3389/fimmu.2024.1294807

Advances in understanding of dendritic cell in the pathogenesis of acute kidney injury

Front Immunol. 2024 Feb 16:15:1294807. doi: 10.3389/fimmu.2024.1294807. eCollection 2024.

Authors

Dongfang Lv¹, Huihui Jiang², Xianzhen Yang³, Yi Li^{4

5}, Weipin Niu^{6

7}, Denglu Zhang^{6

7}

Affiliations

¹ College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
² Clinical Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
³ Department of Urology, Afliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
⁴ Department of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
⁵ Engineering Laboratory of Urinary Organ and Functional Reconstruction of Shandong Province, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
⁶ Central Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
⁷ Shandong Key Laboratory of Dominant Diseases of traditional Chinese Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Abstract

Acute kidney injury (AKI) is characterized by a rapid decline in renal function and is associated with a high morbidity and mortality rate. At present, the underlying mechanisms of AKI remain incompletely understood. Immune disorder is a prominent feature of AKI, and dendritic cells (DCs) play a pivotal role in orchestrating both innate and adaptive immune responses, including the induction of protective proinflammatory and tolerogenic immune reactions. Emerging evidence suggests that DCs play a critical role in the initiation and development of AKI. This paper aimed to conduct a comprehensive review and analysis of the role of DCs in the progression of AKI and elucidate the underlying molecular mechanism. The ultimate objective was to offer valuable insights and guidance for the treatment of AKI.

Keywords: acute kidney injury; dendritic cells; protective proinflammatory; tolerogenic dendritic cells; tolerogenic immune reactions.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury* / etiology
Cognition
Dendritic Cells
Humans

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by the National Natural Science Foundation of China (grant numbers 82074171, 82003611 and 81700592).