Context matters for addressing controversies in FGF21 biology

Chih-Ting Wu; Karen K Ryan

doi:10.1016/j.tem.2024.02.013

Context matters for addressing controversies in FGF21 biology

Trends Endocrinol Metab. 2024 Apr;35(4):280-281. doi: 10.1016/j.tem.2024.02.013. Epub 2024 Mar 1.

Authors

Chih-Ting Wu¹, Karen K Ryan²

Affiliations

¹ Department of Neurobiology, Physiology, and Behavior, University of California, 1 Shields Avenue, Davis, CA 95616, USA.
² Department of Neurobiology, Physiology, and Behavior, University of California, 1 Shields Avenue, Davis, CA 95616, USA. Electronic address: kkryan@ucdavis.edu.

PMID: 38431438
DOI: 10.1016/j.tem.2024.02.013

Abstract

Recent discoveries by Solon-Biet and colleagues highlight the importance of nutritional context for addressing current controversies in Fibroblast Growth Factor 21 (FGF21) biology. Through a series of complex studies, the authors explored the physiological and pharmacological effects of FGF21 on feeding behavior and energy balance under differing nutritional and metabolic statuses.

MeSH terms

Biology
Energy Metabolism
Feeding Behavior*
Fibroblast Growth Factors* / metabolism
Humans

Substances

fibroblast growth factor 21
Fibroblast Growth Factors