Grade 5 Radiation Necrosis After Whole-Brain Radiation Therapy

Andrew Tam; Yun Rose Li; Terence Williams; Stephanie Yoon

doi:10.1016/j.prro.2023.10.012

Grade 5 Radiation Necrosis After Whole-Brain Radiation Therapy

Pract Radiat Oncol. 2024 Mar-Apr;14(2):87-92. doi: 10.1016/j.prro.2023.10.012.

Authors

Andrew Tam¹, Yun Rose Li², Terence Williams², Stephanie Yoon³

Affiliations

¹ Department of Radiation Oncology, City of Hope National Cancer Center, Duarte, California.
² Department of Radiation Oncology, City of Hope National Cancer Center, Duarte, California; Beckman Research Institute, City of Hope National Cancer Center, Duarte, California.
³ Department of Radiation Oncology, City of Hope National Cancer Center, Duarte, California. Electronic address: styoon@coh.org.

PMID: 38431371
DOI: 10.1016/j.prro.2023.10.012

Abstract

Whole-brain radiation treatment is often considered for patients with leptomeningeal disease. There are limited reports of the development of radiation necrosis after whole-brain radiation treatment and fewer associating the presence of germline mutations with risk. We present a case report to highlight the need for consideration of radiosensitizing mutations when recommending radiation therapy.

Publication types

Case Reports

MeSH terms

Brain / diagnostic imaging
Brain Neoplasms* / complications
Brain Neoplasms* / radiotherapy
Cranial Irradiation / adverse effects
Humans
Necrosis / etiology