A potential mechanism for the cytoprotective effects of activated protein C-released endothelial extracellular vesicles

Kaushik Das; Shiva Keshava; Tanmoy Mukherjee; L Vijaya Mohan Rao

doi:10.1182/blood.2023023518

A potential mechanism for the cytoprotective effects of activated protein C-released endothelial extracellular vesicles

Blood. 2024 Apr 18;143(16):1670-1675. doi: 10.1182/blood.2023023518.

Authors

Kaushik Das¹, Shiva Keshava¹, Tanmoy Mukherjee¹, L Vijaya Mohan Rao¹

Affiliation

¹ Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.

PMID: 38427750
PMCID: PMC11103092 (available on 2025-04-18)
DOI: 10.1182/blood.2023023518

Abstract

Activated protein C (APC) was shown to release extracellular vesicles (EVs). APC bound to the EVs was thought to be responsible for cytoprotection. Our study demonstrates that the cytoprotective effects of APC-released EVs are independent of APC. APC-released EVs carry anti-inflammatory microRNAs in their cargo.

MeSH terms

Cell Communication
Cytoprotection*
Endothelial Cells / metabolism
Extracellular Vesicles* / metabolism
Humans
MicroRNAs / metabolism
Protein C* / metabolism

Substances

MicroRNAs
Protein C