Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia

Lena Blumel; Flavia Bernardi; Daniel Picard; Jacob Torrejon Diaz; Vera H Jepsen; Rebecca Hasselmann; Julian Schliehe-Diecks; Jasmin Bartl; Nan Qin; Beat Bornhauser; Sanil Bhatia; Blerim Marovka; Veronique Marsaud; Florent Dingli; Damarys Loew; Martin Stanulla; Jean-Pierre Bourqin; Arndt Borkhardt; Marc Remke; Olivier Ayrault; Ute Fischer

doi:10.3324/haematol.2023.283928

Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia

Haematologica. 2024 Feb 29. doi: 10.3324/haematol.2023.283928. Online ahead of print.

Authors

Lena Blumel¹, Flavia Bernardi², Daniel Picard¹, Jacob Torrejon Diaz², Vera H Jepsen³, Rebecca Hasselmann³, Julian Schliehe-Diecks³, Jasmin Bartl⁴, Nan Qin¹, Beat Bornhauser⁵, Sanil Bhatia³, Blerim Marovka⁵, Veronique Marsaud², Florent Dingli⁶, Damarys Loew⁶, Martin Stanulla⁷, Jean-Pierre Bourqin⁵, Arndt Borkhardt³, Marc Remke¹, Olivier Ayrault², Ute Fischer⁸

Affiliations

¹ Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.
² Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay.
³ Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.
⁴ Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf, Germany; Group for Interdisciplinary Neurobiology and Immunology - INI-research, Institute of Zoology, University of Hamburg, Hamburg.
⁵ Department of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich.
⁶ Institut Curie, PSL Research University, Centre de Recherche, CurieCoreTech Spectrometrie de Masse Proteomique, Paris.
⁷ Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover.
⁸ Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf. ute.fischer@med.uni-duesseldorf.de.

PMID: 38426288
DOI: 10.3324/haematol.2023.283928

Abstract

Not available.