What Is the Evidence Supporting Osteobiologic Use in Revision Anterior Cervical Discectomy and Fusion?

Sathish Muthu; Sara Elisa Diniz; Vibhu Krishnan Viswanathan; Patrick C Hsieh; Aidin Abedi; Tim Yoon; Hans Jörg Meisel; Zorica Buser; Ricardo Rodrigues-Pinto; Ao Spine Knowledge Forum Degenerative

doi:10.1177/21925682221133751

What Is the Evidence Supporting Osteobiologic Use in Revision Anterior Cervical Discectomy and Fusion?

Global Spine J. 2024 Feb;14(2_suppl):173S-178S. doi: 10.1177/21925682221133751.

Authors

Sathish Muthu^{1

2}, Sara Elisa Diniz³, Vibhu Krishnan Viswanathan^{2

4}, Patrick C Hsieh⁵, Aidin Abedi^{6

7}, Tim Yoon⁸, Hans Jörg Meisel⁹, Zorica Buser^{10

11}, Ricardo Rodrigues-Pinto^{3

12

13}, Ao Spine Knowledge Forum Degenerative¹⁴

Affiliations

¹ Department of Orthopaedics, Government Medical College, Dindigul, India.
² Orthopaedic Research Group, Coimbatore, Tamil Nadu, India.
³ Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal.
⁴ Department of Musculoskeletal Oncology, University of Calgary, Alberta, CA.
⁵ Department of Neurological Surgery, USC Spine Center, Keck School of Medicine, Los Angeles, CA, USA.
⁶ Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁷ USC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁸ Department of Orthopaedics, Emory University, Atlanta, GA, USA.
⁹ Department of Neurosurgery, BG Klinikum Bergmannstrost Halle, Germany.
¹⁰ Gerling Institute, Brooklyn, NY, USA.
¹¹ Department of Orthopedic Surgery, NYU Grossman School of Medicine, New York, USA.
¹² Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal.
¹³ Hospital CUF Trindade, Porto, Portugal.
¹⁴ AO Spine, AO Foundation, Davos, Switzerland.

Abstract

Study design: Systematic literature review.

Objective: To analyze the literature and describe the evidence supporting osteobiologic use in revision anterior cervical discectomy and fusion (ACDF) surgery.

Methods: A systematic search of PubMed/MEDLINE, EMBASE, Cochrane library, and ClinicalTrials.gov databases was conducted for literature reporting the use of osteobiologics in revision ACDF. We searched for studies reporting outcomes of using any osteobiologic use in revision ACDF surgeries (independently of the number of levels) in the above databases.

Results: There are currently no studies in the literature describing the outcome and comparative efficacy of diverse osteobiologic agents in the context of revision ACDF surgery. A majority of the current evidence is based only upon studies involving primary ACDF surgery.

Conclusion: The current study highlights the paucity of literature evidence on the role of diverse osteobiologics in revision ACDF, and foregrounds the need for high-quality evidence on this subject.

Keywords: ACDF; anterior cervical discectomy and fusion; osteobiologics; reoperation; revision surgery.