Shenfu injection: a review of pharmacological effects on cardiovascular diseases

Fei-Fei Xu; Xiao-Fang Xie; Hai-Yan Hu; Rong-Sheng Tong; Cheng Peng

doi:10.3389/fphar.2024.1279584

Shenfu injection: a review of pharmacological effects on cardiovascular diseases

Front Pharmacol. 2024 Feb 14:15:1279584. doi: 10.3389/fphar.2024.1279584. eCollection 2024.

Authors

Fei-Fei Xu^{1

2}, Xiao-Fang Xie¹, Hai-Yan Hu³, Rong-Sheng Tong², Cheng Peng¹

Affiliations

¹ State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
³ Sichuan Nursing Vocational College, Chengdu, China.

Abstract

Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Shenfu Decoction created more than 700 years ago. SFI has been widely used in China for over 30 years for treating cardiovascular diseases. The main components in it include ginsenosides and aconitum alkaloids. In recent years, the role of SFI in the treatment of cardiovascular diseases has attracted much attention. The pharmacological effects and therapeutic applications of SFI in cardiovascular diseases are summarized here, highlighting pharmacological features and potential mechanisms developments, confirming that SFI can play a role in multiple ways and is a promising drug for treating cardiovascular diseases.

Keywords: Shenfu injection; TCM (traditional Chinese medicine); cardiovascular disease; clinical trial; heart failure; pharmacology.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Sichuan Province Natural Science Foundation Program (Grant NO. 24NSFSC0627); “Xinglin Scholars” Nursery Talent Special Program (grant number MPRC2023032).